Expectoration disturbances in patients with COPD

V. N. Solopov, I. V. Lunichkina

Expectoration disturbances in patients with COPD

Soviet Association of aid to patients with cystic fibrosis
Pogodinscaya 8 — 2, 119121 Moscow, USSR.

We developed a method of estimation of the evacuation time (expectoration time) (Texp) of bronchial contents stained with haemoglobin (Hb) in patients with COPD. 155 patients were examined: 44 with intrinsic asthma, 111 with chronic bronchitis. It was found that Texp depends on the type of illness (X±m): asthma 41.5±4.4 h, non-obstructive 31.4±4.2 h., obstructive 64.7±4.3 h and pyo-obstructive bronchitis 116.1±7.8 h. Expectoration efficacy during a comparison of different drugs amounted to (X±m): 1) peroral: ambroxol 41.5±5.1%, bromhexine 37.9±8.6%, Mucodyne 30.4±7.6%; 2) inhalation: n-acetyl-cysteine 55.3±5.3%, 2% solution of sodium bicarbonate 58.4±3.8%, sodium bicarbonate in a dry aerosol form 52.5±9.7%. Conclusion: the choice of drug and introduction manner (peroral or inhalation) must be determined by the value of the expectoration time.

The European Respiratory Journal, 1990, Vol. 3, Suppl. 10, P1766.

Diagnostic program for investigating mucociliar transport in patients with chronic nonspecific diseases of the lungs

A. G. Chuchalin, V. N. Solopov, N. A. Kolganova

DIAGNOSTIC PROGRAM FOR INVESTIGATING MUCOCILIAR TRANSPORT
IN PATIENTS WITH CHRONIC NONSPECIFIC DISEASES OF THE LUNGS

Indices of mucociliar transport: its rate and sputum reological properties were studied. Data indicative of close relation between mucociliar transport disorders and obstructive syndrome are presented. Possible mechanisms of bronchial patency impairment are discussed. A differential approach to therapy aimed at bronchial patency correction is exemplified clinically.

«Problemy Tuberculosa» 1988, №8, с. 13-1

The diagnosis of mucociliary insufficiency

THE DIAGNOSIS OF MUCOCILIARY INSUFFICIENCY

V. N. Solopov, I. V. Lunichkina

Summary

The data on the diagnosis of mucociliary insufficiency (MCI) are reviewed for patients with chronic obstructive pulmonary diseases. MCI is characterized as the condition of more rapid accumulation of bronchial secretion in comparison to its evacuation, the residual secretion being the cause of the onset of the obturation syndrome. It is suggested that MCI detection be determined by expectoration time — the time of bronchial secretion evacuation following inhalation of the indicator substance. Two methods of mucociliary transport assessment are compared: the modified one and that by autologous hemogblobin. The compatibility of the results is thought evidence of a valid assessment of mucociliary transport by expectoration time.

«Klin. Med.» (Msk) 1989, №7, с. 49-52.